How does it work?

1. Primary B cells engineered to express biologic
2. Engineered B cells engrafted into mice
3. Mice immunized with drug target
4. Engineered cells affinity mature in germinal centers
5. Improved clones isolated and characterized

Why does it work?

1. Innovative editing method promotes somatic hypermutation
2. Genuine mammalian post-translational modifications
3. Affinity maturation efficiently explores sequence space
4. Selects against sequences with poor in vivo behavior